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| BAATARTSOGT, Tugsbaatar; N. BUI, Vuong; Q. TRINH, Dai; YAMAGUCHI, Emi; GRONSANG, Dulyatad; THAMPAISARN, Rapeewan; OGAWA, Haruko; IMAI, Kunitoshi; 小川, 晴子; 今井, 邦俊. |
| Viral neuraminidase inhibitors are widely used as synthetic anti-influenza drugs for the prevention and treatment of influenza. However, drug-resistant influenza A virus variants, including H5N1 highly pathogenic avian influenza viruses (HPAIVs), have been reported. Therefore, the discovery of novel and effective antiviral agents is warranted. We screened the antiviral effects of 11 herbal tea extracts (hibiscus, black tea, tencha, rosehip tea, burdock tea, green tea, jasmine tea, ginger tea, lavender tea, rose tea and oak tea) against the H5N1 HPAIV in vitro. Among the tested extracts, only the hibiscus extract and its fractionated extract (frHibis) highly and rapidly reduced the titers of all H5 HPAIVs and low pathogenic AIVs (LPAIVs) used in the... |
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Palavras-chave: Antiviral effect; H5N1; Herbal tea extract; Hibiscus. |
| Ano: 2016 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4349 |
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| ARAI, Yasuha; N. BUI, Vuong; TAKEDA, Yohei; Q. TRINH, Dai; NIBUNO, Sayo; RUNSTADLER, Jonathan; OGAWA, Haruko; IMAI, Kunitoshi; 小川, 晴子. |
| The lung cytokine gene expression profiles of mice infected with 2 strains of H4N8 viruses isolated from shorebirds and reference H4 viruses from ducks are compared. Major differences between the two H4N8 strains of shorebirds, one of which causes a severe respiratory disease in mice, are in the PB1 and NS1 genes. In mice with H4N8 virus induced pneumonia, overall expression of TNF-α, IL-6 and IL-12 genes was markedly higher than in mice infected with other H4 viruses tested, although gene expression of type I interferon was not increased until day 4 post viral infection. In contrast, in mice infected with a comparison H4N8 strain, gene expression of type I interferon peaked on day 1 post viral infection. Overall, the cytokine response corresponds with the... |
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Palavras-chave: Avian influenza virus; Cytokine; H4N8; Mouse; Pathogenicity. |
| Ano: 2013 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4061 |
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